Publications

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A common haplotype of interferon regulatory factor 5 (IRF5) regulates splicing and expression and is associated with increased risk of systemic lupus erythematosus Robert R Graham, Sergey V Kozyrev, Emily C Baechler, MV Prasad Linga Reddy, Robert M Plenge, Jason W Bauer, Ward A Ortmann, Thearith Koeuth, Ma Francisca Gonzalez Escribano, the Argentine and Spanish Collaborative Groups, Bernardo Pons-Estel, Michelle Petri, Mark Daly, Peter K Gregersen, Javier Martin, David Altshuler, Timothy W Behrens & Marta E Alarcon-Riquelme Nature Genetics - published online 16 April 2006; doi:10.1038/ng1782 - PDF -

Genomic view of systemic autoimmunity in MRLlpr mice J Liu, G Karypis, KL Hippen, AL Vegoe, P Ruiz, GS Gilkeson, and TW Behrens Genes and Immunity (2006) 7 - PDF -

In Vivo Assessment of the Relative Contributions of Deletion, Anergy, and Editing to B Cell Self-Tolerance Keli L. Hippen, Brian R. Schram, Lina E. Tze,3 Kathryn A. Pape, Marc K. Jenkins, and Timothy W. Behrens The Journal of Immunology, 2005, 175: 909–916 - PDF -

Basal Immunoglobulin Signaling Actively Maintains Developmental Stage in Immature B Cells Lina E. Tze, Brian R. Schram, Kong-Peng Lam, Kristin A. Hogquist, Keli L. Hippen, Jiabin Liu1, Susan A. Shinton, Kevin L. Otipoby, Peter R. Rodine, Amanda L. Vegoe, Manfred Kraus, Richard R. Hardy, Mark S. Schlissel, Klaus Rajewsky, Timothy W. Behrens PLoS Biol. 2005 Mar;3(3):e82. Epub 2005 Mar 8. - PDF -

Analysis of Families in the Multiple Autoimmune Disease Genetics Consortium (MADGC) Collection: the PTPN22 620W Allele Associates with Multiple Autoimmune Phenotypes Lindsey A. Criswell, Kirsten A. Pfeiffer, Raymond F. Lum, Bonnie Gonzales, Jill Novitzke, Marlena Kern, Kathy L. Moser, Ann B. Begovich, Victoria E. H. Carlton, Wentian Li, Annette T. Lee, Ward Ortmann, Timothy W. Behrens, and Peter K. Gregersen Am. J. Hum. Genet. 76:000–000, 2005 - PDF -

Peripheral blood gene expression profiling in rheumatoid arthritis FM Batliwalla, EC Baechler, X Xiao, W Li, S Balasubramanian, H Khalili, A Damle, WA Ortmann, A Perrone, AB Kantor, PS Gulko, M Kern, R Furie, TW Behrens and PK Gregersen Genes and Immunity (2005) 6, 388–397 - PDF -

Fine mapping chromosome 16q12 in a collection of 231 systemic lupus erythematosus sibpair and multiplex families Gillett CD, Langefeld CD, Williams AH, Ortmann WA, Graham RR, Rodine PR, Selby SA, Gaffney PM, Behrens TW, Moser KL Genes & Immunity, February 2005, Volume 6, Number 1, Pages 19-23 - PDF -

Fatal acute lymphoblastic leukemia in mice transgenic for B cell-restricted bcl-xL and c-myc Swanson PJ, Kuslak SL, Fang W, Tze L, Gaffney P, Selby S, Hippen KL, Nunez G, Sidman CL, Behrens TW. The Journal of Immunology, 2004, 172: 6684–6691. - PDF -

Genetic Association of the R620W Polymorphism of Protein Tyrosine Phosphatase PTPN22 with Human SLE Chieko Kyogoku, Carl D. Langefeld, Ward A. Ortmann, Annette Lee, Scott Selby, Victoria E. H. Carlton, Monica Chang, Paula Ramos, Emily C. Baechler, Franak M. Batliwalla, Jill Novitzke, Adrienne H. Williams, Clarence Gillett, Peter Rodine, Robert R. Graham, Kristin G. Ardlie, Patrick M. Gaffney, Kathy L. Moser, Michelle Petri, Ann B. Begovich, Peter K. Gregersen, and Timothy W. Behrens Am. J. Hum. Genet. 75:504–507, 2004 - PDF -

Interferon-inducible gene expression signature in peripheral blood cells of patients with severe lupus Baechler EC, Batliwalla FM, Karypis G, Gaffney PM, Ortmann WA, Espe KJ, Shark KB, Grande WJ, Hughes KM, Kapur V, Gregersen PK, Behrens TW Proc Natl Acad Sci U S A. 2003 Mar 4;100(5):2610-5. - PDF -

Dissecting the genetic complexity of the association between human leukocyte antigens and rheumatoid arthritis. Jawaheer D, Li W, Graham RR, Chen W, Damle A, Xiao X, Monteiro J, Khalili H, Lee A, Lundsten R, Begovich A, Bugawan T, Erlich H, Elder JT, Criswell LA, Seldin MF, Amos CI, Behrens TW, Gregersen PK. Am J Hum Genet. 2002 Sep;71(3):585-94. - PDF -

Recent advances in the genetics of systemic lupus erythematosus. Gaffney PM, Moser KL, Graham RR, Behrens TW. - PDF -

Visualizing HLA Class II Risk Haplotypes in Human SLE Robert R. Graham, Ward A. Ortmann, Carl D Langefeld, Damini Jawaheer, Scott A. Selby, Peter R. Rodine, Emily C. Baechler, Kristine E Rohlf, Katherine B. Shark, Rajan P. Nair, Philip E. Stuart, James T. Elder, Richard A. King, Kathleen L. Moser, Patrick M. Gaffney, Teodorica L. Bugawan, Henry A. Erlich, Steven S. Rich, Peter K. Gregersen, Timothy W. Behrens Am J Hum Genet. 2002 Sep;71(3):543-53. - PDF -

Delineating the genetic basis of systemic lupus erythematosus. Wakeland EK, Liu K, Graham RR, Behrens TW. Immunity. 2001 Sep;15(3):397-408. Review. - PDF -

Genetic linkage and transmission disequilibrium of marker haplotypes at chromosome 1q41 in human systemic lupus erythematosus. Graham RR, Langefeld CD, Gaffney PM, Ortmann WA, Selby SA, Baechler EC, Shark KB, Ockenden TC, Rohlf KE, Moser KL, Brown WM, Gabriel SE, Messner RP, King RA, Horak P, Elder JT, Stuart PE, Rich SS, Behrens TW Arthritis Res. 2001;3(5):299-305. - PDF -

Ig light chain receptor editing in anergic B cells. Tze LE, Baness EA, Hippen KL, Behrens TW. J Immunol. 2000 Dec 15;165(12):6796-802. - PDF -

PARP alleles and SLE: failure to confirm association with disease susceptibility. Criswell LA, Moser KL, Gaffney PM, Inda S, Ortmann WA, Lin D, Chen JJ, Li H, Gray-McGuire C, Neas BR, Rich SS, Harley JB, Behrens TW, Seldin MF. J Clin Invest. 2000 Jun;105(11):1501-2. No abstract available. - PDF -

Genome screening in human systemic lupus erythematosus: results from a second Minnesota cohort and combined analyses of 187 sib-pair families. Gaffney PM, Ortmann WA, Selby SA, Shark KB, Ockenden TC, Rohlf KE, Walgrave NL, Boyum WP, Malmgren ML, Miller ME, Kearns GM, Messner RP, King RA, Rich SS, Behrens TW. Am J Hum Genet. 2000 Feb;66(2):547-56. - PDF -

A genome-wide search for susceptibility genes in human systemic lupus erythematosus sib-pair families. Gaffney PM, Kearns GM, Shark KB, Ortmann WA, Selby SA, Malmgren ML, Rohlf KE, Ockenden TC, Messner RP, King RA, Rich SS, Behrens TW. Proc Natl Acad Sci U S A. 1998 Dec 8;95(25):14875-9. - PDF -

The genetics of human systemic lupus erythematosus. Harley JB, Moser KL, Gaffney PM, Behrens TW. Curr Opin Immunol. 1998 Dec;10(6):690-6. Review. - PDF -

The role of the clinical rheumatologist in the establishment of a large sibling pair resource for systemic lupus erythematosus. Kearns GM, Messner RP, Behrens TW. J Rheumatol. 1998 Mar;25(3):482-5. - PDF -